How to start the GTA Online Last Dose missions

Labrat balances a pineapple on his head in the GTA Online Last Dose missions
(Image credit: Rockstar Games)

The GTA Online Last Dose missions represent the much-anticipated conclusion to the Los Santos Drug Wars storyline, and you're in for a pretty wild ride with them as you spiral deeper into the realm of drugs, deceit, and dark secrets of the pharmaceutical industry. Some of these experiences warp and twist the world of GTA Online, as you fall foul of the psychedelic schemes instigated by Dr Isiah Friedlander, so you'll need to keep an open mind and go with the flow if you want to emerge victorious. It all begins with a call received from Dax, so here's how you can get started on the Last Dose missions in GTA Online.

How to start the Last Dose missions in GTA Online

An RV races down the highway during the GTA Online Last Dose missions

(Image credit: Rockstar Games)

To start the Last Dose missions in GTA Online, you need to have completed all six of the First Dose missions already – if you haven't done that, then go and visit Dax at The Freakshop to take care of business. With those out of the way, you'll receive a phone call from Dax to go and meet him, which will then set the Last Dose missions into motion. There are five of these, as follows:

  • Last Dose 1 - This is an Intervention
  • Last Dose 2 - Unusual Suspects
  • Last Dose 3 - FriedMind
  • Last Dose 4 - Checking In
  • Last Dose 5 - BDKD

Some players have reported initial problems when starting the GTA Online Last Dose missions, whether that's not receiving the call from Dax, or heading to the first mission marker then finding the prompt to begin it is unresponsive. If either of these are affecting you, then try switching to new sessions or reloading the game – be patient, then eventually you'll get the call and be able to start the new missions. This initial teething problem should have been ironed out, so hopefully you won't experience any issues such as this.

What are the GTA Online Last Dose rewards

Dr Friedlander appears during the GTA Online Last Dose missions

(Image credit: Rockstar Games)

For beating all five of the GTA Online Last Dose missions (along with the previous six First Dose missions) as host, your reward is the Ocelot Virtue belonging to Dr Friedlander, which is one of the GTA Online new cars and may be unavailable elsewhere depending on changes to the store rotation. During the Last Dose event running through March 29 you could also earn the following mission rewards, though these have now expired:

  • Complete Last Dose 1 - This is an Intervention: Floral Guffy Pool Sliders
  • Complete all Last Dose missions: Lime Leopard Slab cap and Canvas Shoes
  • Resupply your GTA Online Acid Lab and complete a Sell mission: Black Enema Flourish Ski mask
  • Complete a GTA Online Stash House: Teal Enema Flourish Ski mask

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Iain Wilson
Guides Editor

Iain originally joined Future in 2012 to write guides for CVG, PSM3, and Xbox World, before moving on to join GamesRadar in 2013 as Guides Editor. His words have also appeared in OPM, OXM, PC Gamer, GamesMaster, and SFX. He is better known to many as ‘Mr Trophy’, due to his slightly unhealthy obsession with amassing intangible PlayStation silverware, and he now has over 750 Platinum pots weighing down the shelves of his virtual award cabinet. He does not care for Xbox Achievements.

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