How to solve the Marvel's Spider-Man 2 Hybrid Calibration puzzle

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This plant DNA puzzle for Heal the World in Spider-Man 2 is about slotting elements together

Spider Man 2 plant hybrid calibration puzzle
(Image credit: Sony Interactive Entertainment)

The Marvel's Spider-Man 2 Hybrid Calibration puzzle is a science experiment during the Heal the World mission, where Harry and Doctor Foster ask you to modify plant DNA to create special kinds of crops for the Emily-May Foundation. It's a puzzle type that comes up a few times over the course of the game so this acts as a kind of tutorial to get to grips with it all. If you want a gene splicing 101, here's our guide on how to solve the Spider-Man 2 Hybrid puzzle, and how you can set yourself up for the further puzzles ahead in Marvel's Spider-Man 2 .

How to solve the plant hybrid puzzle in Spider-Man 2

(Image credit: Sony Interactive Entertainment)

The Spider-Man 2 Hybrid puzzle is solved by slotting certain DNA qualities together at the EMF foundation for Harry and Dr. Foster. We've put the solutions to all three stages above, in the specific order that you'll encounter them, from left to right.

To succeed you need to fulfil the minimum conditions for certain qualities, but it doesn't matter if you go over. For example, note how there's two "leaf" icons in the third puzzle above, despite needing only one, and it's still a successful combination. The lines on the outside of the hexagons determine what each icon can sync up with, so three lines can only click with three lines, etc.

There'll be more puzzles of this type later on, particularly if you pursue the Spider-Man 2 EMF Experiments that unlock later, so it's worth keeping these ideas in mind even after finishing up. This mission if basically the tutorial to a longer-lasting gameplay mechanic.

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Joel Franey
Joel Franey
Guides Editor, GamesRadar+

Joel Franey is a writer, journalist, podcaster and Very Tired Man with a BA from Brunel University, a Masters from Sussex University and a decade working in games journalism, often focused on guides coverage but also in reviews, features and news. His love of games is strongest when it comes to groundbreaking narratives like Disco Elysium, UnderTale and Baldur's Gate 3, as well as innovative or refined gameplay experiences like XCOM, Sifu, Arkham Asylum or Slay the Spire. He is a firm believer that the vast majority of games would be improved by adding a grappling hook, and if they already have one, they should probably add another just to be safe. You can find old work of his at Eurogamer, Gfinity, USgamer, SFX Magazine, RPS, Dicebreaker, VG247, and more.